Philadelphia is known as the Birthplace of the Nation because of its role in America’s struggle for independence from Britain. Both the Declaration of Independence and the Constitution of the United States were drafted in the city. The name Philadelphia was derived from the Greek words meaning “city of brotherly love,” and Penn opened his city to people of many different religious and ethnic backgrounds.

Philadelphia is also an important center for medicine, a distinction that it has held since the colonial period, when Pennsylvania Hospital was North America's first hospital. The University of Pennsylvania, the city's largest private employer, runs an extensive medical system.

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